Trimetoprim
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Trimetoprim, atau namo pasarannyo Primsol,[1] adolah antibiotik nan digunoan untuak mangatasi infeksi bakteri takah radang talingo tangah jo inpeksi saluran kamiah.[2] Ubek ko bisa lo digunokan sarentak jo sulfametoksazol atau dapson untuak pangubatan pneumonia pneumocystis pado pandarito HIV/AIDS.[1][3] Ubek ko tamasuak ka dalam Daftar Ubek Esensial Organisasi Kasihatan Dunia sabagai ciek dari banyak ubek nan paliang aman jo efektif nan diparaluan untuak sistem kasihatan.[4]
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| Data klinis | |
|---|---|
| Palafalan | /traɪˈmɛθəprɪm/ |
| Namo dagang | Proloprim, Monotrim, Triprim, dan lain-lain |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a684025 |
| Lisensi data |
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| Kategori pado kahamilan | |
| Rute masuak ubek | Oral (muluik) |
| Kode ATC | |
| Status legal | |
| Status legal | |
| Farmakokinetik data | |
| Bioavailabilitas | 90–100% |
| Ikatan protein | 44% |
| Metabolisme | Hati |
| Eliminasi wakatu paruah | 8-12 jam |
| Ekskresi | Kajamban (50–60%), feses (4%) |
| Pangenal | |
5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine
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| Nomor CAS | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| PDB ligand | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.010.915  |
| Data kimia jo fisika | |
| Formula | C14H18N4O3 |
| Molar mass | 290.32 g/mol g·mol−1 |
| 3D model (JSmol) | |
Nc1nc(N)ncc1Cc(cc2OC)cc(OC)c2OC | |
InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)  Key:IEDVJHCEMCRBQM-UHFFFAOYSA-N | |
| (verify) | |
Rujuakan suntiang
- ↑ a b "Trimethoprim" (dalam bahasa Inggris). The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 24 September 2015.
- ↑ "Trimethoprim" (dalam bahasa Indonesia). Alo Dokter.
- ↑ Masur, H; Brooks, JT; Benson, CA; Holmes, KK; Pau, AK; Kaplan, JE; National Institutes of, Health; Centers for Disease Control and, Prevention; HIV Medicine Association of the Infectious Diseases Society of, America (Mei 2014). "Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America". Clinical Infectious Diseases. 58 (9): 1308–11. doi:10.1093/cid/ciu094. PMC 3982842
. PMID 24585567.
- ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 24 April 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
