Asetilsistein
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Acetylcysteine, tanamo juo jo N-acetylcysteine, adolah ubek nan digunoan untuak maubeki overdosis parasetamol, jo malonggarkan lendir kental pado individu jo fibrosis kistik atau panyakik paru obstruktif kronis. Ubek ko dapek diambiak sacaro intravena, lewat muluik, atau dihiruik sabagai kabuik.
Data klinis | |
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Palafalan | /əˌsiːtəlˈsɪstiiːn/ and similar (/əˌsɛtəlʔ,_ˌæsᵻtəlʔ,_ʔtiːn/) |
Namo dagang | Acetadote, Fluimucil, Mucomyst, lainnyo |
Namo lain | N-acetylcysteine; N-acetyl-L-cysteine; NALC; NAC |
AHFS/Drugs.com | Monograph |
Lisensi data |
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Kategori pado kahamilan | |
Rute masuak ubek | lewat muluik, injeksi, inhalasi |
Kode ATC | |
Status legal | |
Status legal | |
Farmakokinetik data | |
Bioavailabilitas | 10% (Oral)[2] |
Ikatan protein | 50 hinggo 83%[1] |
Metabolisme | Hati[1] |
Eliminasi wakatu paruah | 5.6 jam[3] |
Ekskresi | Renal (30%),[1] faecal (3%) |
Pangenal | |
(2R)-2-acetamido-3-sulfanylpropanoic acid[4]
| |
Nomor CAS | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.009.545 |
Data kimia jo fisika | |
Formula | C5H9NO3S |
Molar mass | 163.195 g·mol−1 |
3D model (JSmol) | |
Specific rotation | +5° (c = 3% in water)[5] |
Melting point | 109 to 110 °C (228 to 230 °F) [5] |
C/C(=N/[C@@H](CS)C(=O)O)/O | |
InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1 Key:PWKSKIMOESPYIA-BYPYZUCNSA-N | |
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Referensi
suntiang- ↑ a b c "Acetylcysteine". The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 23 September 2015.
- ↑ Stockley, Robert A. (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management.. Chichester: John Wiley & Sons. p. 750. ISBN 9780470755280. https://books.google.com/books?id=y9li1geShyYC&pg=PA750.
- ↑ "ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]". DailyMed. Cumberland Pharmaceuticals Inc. June 2013. Diarsipkan dari versi asli tanggal 13 January 2014. Diakses tanggal 8 November 2013.
- ↑ "L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Diarsipkan dari versi asli tanggal 12 January 2014.
- ↑ a b "N-ACETYL-L-CYSTEINE Product Information" (PDF). Sigma. Sigma-aldrich. Diarsipkan dari versi asli (PDF) tanggal 11 June 2014.