Pacquiao lahia di Kibawe, [[Bukidnon]], jo gadang di [[Kota General Santos|General Santos]], Filipina. Inyo adolah anak dari Rosalio Pacquiao jo Dionisia Dapidran-Pacquiao.[19]<ref name="parents">{{cite web |url=http://www.doghouseboxing.com/DHB/Robert111009.htm |title=Manny Pacquiao's Mom and Dad Reunited? |author=Robbie Pangilinan |date=November 9, 2009 |work=Doghouse Boxing |accessdate=March 15, 2010}}</ref> Apak jo amaknyo bacarai kutiko inyo kaleh anam.[19]<ref name="parents" /> Inyo anak kaampek dari anam basudaro, nan salah satunyo Alberto "Bobby" Pacquiao adolah surang politikus jo mantan patinju profesional pulo.
Pacquiao manyalasaian pandidiakan dasanyo di SD Saavedra Saway di Kota General Santos, tatapi sudah tu inyo putuih sikola dek alasan kamiskinan nan parah.<ref name="time">{{cite news|author=Howard Chua-Eoan and Ishaan Tharoor|date=November 16, 2009|title=The Meaning and Mythos of Manny Pacquiao|work=Time.com|publisher=[20[Time (magazine)|Time]]|url=http://www.time.com/time/magazine/article/0,9171,1935091,00.html|accessdate=March 15, 2010}}</ref> Pado umua 12 taun, Pacquiao manganal tinju malalui mamaknyo, Sardo Mejia. Pacquiao mangato dalam otobiografinyo bahaso manyaksian kakalahan [[Mike Tyson]] dari [[James Douglas|James "Buster" Douglas]] pado taun 1990 basamao Mamak Sardo adolah pangalaman nan "mangubah iduik ambo salamonyo." Minaik awanyo dalam ulahrago pataruangan tainspirasi juo dek ahli bela diri [[Bruce Lee]] jo patinju [[Muhammad Ali]].<ref>{{cite [21]news|last1=Bishop|first1=Greg|date=1 May 2011|title=Pacquiao’s Style Takes Inspiration From Bruce Lee|work=[22[The New York Times]]|url=https://www.nytimes.com/2011/05/02/sports/02pacquiao.html|accessdate=16 January 2020}}</ref><ref>{{cite news|date=June 5, 2016|title=Pacquiao: Muhammad Ali was a huge inspiration|work=ABS-CBN News|url=https://news.abs-cbn.com/sports/06/04/16/pacquiao-muhammad-ali-was-a-huge-inspiration|accessdate=16 January 2020}}</ref>
